UK regulators scrutinize drug trial data while NHS reports patient safety failures; new research emerges on stroke risk factors, cancer screening improvements, and treatment innovations across multiple conditions.

The UK's MHRA has launched a review into the integrity of trial data supporting avacopan's licence for ANCA-associated vasculitis treatment, raising concerns about the drug's approval foundation.

NHS England documented 403 'never events' in 2025-26, including wrong-site surgeries, retained foreign objects in patients, and incorrect blood transfusions, highlighting persistent patient safety gaps across the health system.

The Royal College of Psychiatrists warns that women's mental health needs are systematically overlooked despite women experiencing higher rates of common mental disorders, calling for systemic reforms.

A study reveals that individuals undergoing syphilis testing face substantially elevated stroke risk compared to the general population, regardless of test results, suggesting syphilis testing may indicate underlying cardiovascular vulnerability.

DNA methylation markers show high diagnostic accuracy in identifying high-grade cervical intraepithelial neoplasia and cervical cancer, potentially improving triage and early detection strategies.

Early treatment with baricitinib in undifferentiated arthritis patients produces greater 3-month improvements in disease activity compared to NSAID-based symptomatic treatment alone.

Oral glucocorticoid use demonstrates a dose-dependent increase in candidemia risk, with particularly strong effects observed in inflammatory bowel disease patients using these medications.

Emergency department patients receiving serratus anterior plane blocks for acute rib fractures experienced significant pain reduction and improved functional recovery beyond standard care alone.